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نشر بحث بعنوان "تصنيع الأدوية عبر الطباعة ثلاثية الأبعاد"
 
تاريح النشر 2021.05.05
 
نشر بحث بعنوان "تصنيع الأدوية عبر الطباعة ثلاثية الأبعاد"
 
قام الدكتور جهاد من قسم العلوم الصيدلانية بنشر دراسة بحثية بعنوان "تصنيع الأدوية عبر الطباعة ثلاثية الأبعاد".
يهدف هذه البحث إلى دراسة تأثير مسامات السطح على حركية الدواء وسرعة ايصاله.
مختصر عن البحث الذي تم نشره في افضل المجلات العلمية في هذا المجال:

3D printing has the unique ability to produce porous pharmaceutical solid dosage forms on-demand. Although using porosity to alter drug release kinetics has been proposed in the literature, the effects of porosity on the swellable and erodible porous solid dosage forms have not been explored. This study used a model formulation containing HPMCAS, PEO and paracetamol to examine the porosity effects on drug release. The pores were created by altering the infill percentages of the 3D printing. The 3D printed formulation swelled in pH 1.2 and eroded in pH 6.8 PBS. A newly developed thermal droplet-deposition 3D printing method, Arburg plastic free-forming (APF), was used to compare with conventional material extrusion, commonly referred to as fused deposition modelling (FDM) for fabricating the porous tablets with a wide range of infills. This is the first study reporting the use of APF on 3D printing porous pharmaceutical tablets. With the unique pellet feeding mechanism of APF, it is important to explore its potential applications in pharmaceutical additive manufacturing. APF was able to print porous tablets with 20 to 100% infill. The kinetic analysis of the in vitro drug release data demonstrated the direct correlation between drug release rate and tablet infill. Tablets with 60-90% infill showed no significant differences due to the swelling of the roads which reduced the pore size during dissolution. The results revealed that drug release kinetics were controlled by the complex interplay of the porosity and dynamic changes of the tablets caused by swelling and erosion. It also highlighted for the first time the significant impact of fluid hydrodynamics on the in vitro data collection and interpretation of porous solids.


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